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TBDMS offers excellent stability for protecting 2’-hydroxyl of ribonucleosides during acid detritylation and oxidation steps
Transcription & RNA Synthesis
[2] Caruthers
Used in IVT systems to generate high-quality and modified mRNA with improved performance
pseudouridine can reduce innate immune recognition compared with unmodified uridine and improve RNA stability and translational performance
DMT-2'-O-Me-A(Bz)-CE Phosphoramidite Amount/Package:0.5g / 30mL screwed bottle-28 TBDMS offers excellent stability forDMT 2' O Me A(Bz) CE Phosphoramidite is a 2' OMe phosphoramidite monomer used for solid phase oligonucleotide synthesis. It contains a 5' dimethoxytrityl (DMT) protecting group for 5' hydroxyl protection, a benzoyl (Bz) base protecting group on adenine, a cyanoethyl (CE) protecting group on phosphite, and a 2' O methyl (2' OMe) ribose modification The 2' OMe modification improves duplex stability, reduces immunogenicity, and significantly increases
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